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Penelitian

Prof. Dr. Suhartono Taat Putra, dr., MS

taatputra@yahoo.com

Fakultas Kedokteran / Departemen Patologi Anatomi

Tim Peneliti :

  1. Askandar Tjokroprawiro
  2. Suhartono Taat Putra
  3. Siti Nur Chusnul Yusmiati --> Peneliti Utama
  4. Arsiniati Mb-arbai

Tahun : 2008

Halaman Naskah : 53 halaman

Sumber Dana :

Besaran Dana : 0

SK. Penetapan : SK Rektor Unair No. 7423/J03/PP/2008

Publikasi : Seminar : Potensi Antioksidan Dlam Ekstrak Teh Merah (Hibiscus Sabdariffa) dan Teh Hijau (Camellia sinensis) Terhadap Proses Aterogenesis Pda tikus Dengan Diet Aterogenik

Kategori Penelitian : Kesehatan

Posting : 03-04-2012

Visitor : 4943


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Title :

ANTIOXIDANT POTENTIAL OF THE EXTRACT OF GREEN TEA (Camellia sinensis) AND RED TEA (Hibiscus sabdariffa) IN ATHEROGENESIS PROCESS IN RATS WITH ATHEROGENIC DIET

Author : Prof. Dr. Suhartono Taat Putra, dr., MS


Year : 2008

Abstact :

Tea is a drink that is consumed   by various levels of community in many countries. Tea is the second most-commonly consumed liquid after water. Several epidemiological studies indicated that polyphenol consumption of green tea as well as other herbal polyphenol may reduce the incidence rate of degenerative diseases, particularly the risk of atherosclerosis. Therefore, the potential and the antioxidant mechanism of the extract of green tea (Camellia sinensis) and red tea (Hibiscus sabdariffa) on the prevention of endothelial dysfunction should be studied further. The potential and the mechanism of preventive effect of green, tea (Camellia sinensis) and red tea (Hibiscus sabdanffa) extract to oxidative stress and atherosclerosis

The objective of this study was to disclose the preventive effect of the administration of green tea (Camellia sinensis) and red tea (Hibiscus sabdanffa) extract to oxidative stress and atherosclerosis in rats given with atherogenic diet.

This was a laboratory experimental study using separate sample pretest -post­ test control group design. The experimental animals of Wistar strain Rattus norvegicus were randomly divided into seven groups, 1 pretest group, 4 treatment groups, i.e., atherogenic and read tea of 150 mg (A+TMI50), atherogenic and read tea of 300 mg (A+TM300), atherogeric and green tea 150 mg (A+TH150) and atherogenic and green tea 300mg (A+TH300), and 2 control groups normal diet (ND) and atherogenic diet (AD). Each group consist of four rats . The length of the treatment was 8 weeks. Parameters measured was foam cells count, ADMA level, F2-isoprostan, and SOD levels in aortic endothelial tissue, and ADAM F2­-isoprostan and SOD levels in the serum. Data were analyzed muitivariately using computerized statistical program.

The result revealed that foam cell count in endothelial tissue of AD group was significantly higher (p < 0.05) compared to that in ND group, and so were the F2 isoprostan and ADMA levels both in endothelial tissue and serum. SOD activity either in endothelial tissue or serum in AD group was sigmficantly lower (p < 0.05) than that in ND. In all treatment groups (A+TM150, A+TM300, A+TH150, A+TH300), the four parameters showed significant difference (p < 0.05) as compared to AD. The highest reduction of roam cells was found in A+TH150 group The highest reduction of ADMA in tissue and serum was found in A+TM300 group. The highest reduction of F2 isoprostan in endothelial tissue and serum was found in A+TM300 group. The highest increase of SOD in endothelial tissue and serum was found in A+TH300. The result of discriminant analysis revealed that the discriminator variable of atherosclerosis in the tissue was foam cell, SOD, and F2-isoprostan, while the discriminator variable of atherosclerosis in the serum was SOD.

In conclusion, atherogenic diet given for 8 weeks successfully induced an oxidative stress and atherosclerosis in rats. The administration of green tea and read tea in all doses was able to reduce foam cell count, F2-isoprostan, and ADMA, either in the tissue or serum, which is induced by the atherogenic diet and increased SOD activity, both in the tissue and serum. The preventive mechanism of red and green tea extract against atherosclerosis is by relieving oxidative stress through the increase of SOD activity


Keyword : atherogenic diet, red tea (Hibiscus sabdariffa), green tea (Camellia sinensis), foam cell, ADMA, F2-isoprostan, SOD,


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