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Penelitian

Lailatul Muniroh, SKM, M.Kes

lailagizi@gmail.com

Fakultas Kesehatan Masyarakat / Departemen Gizi Kesehatan Masyarakat

Tim Peneliti :

  1. Lailatul Muniroh --> Peneliti Utama
  2. Triska Susila Nindya
  3. Santi Martini
  4. Rondius Solfaine, Drh.,mp

Tahun : 2010

Halaman Naskah : 8 halaman

Sumber Dana : Dikti

Besaran Dana : 71000000

SK. Penetapan : 171/SP2H/PP/DP2M/V/2009

Publikasi : Media Jurnal : Makara Seri Kesehatan

Kategori Penelitian : Kesehatan

Posting : 12-03-2012

Visitor : 5374


Download Article : PDF 2756 byte.


Title :

Curcuma Domestica Volatile Oil (Curcuma domestica, Val) as Anti Inflamation Agent on Gout Arthritis Patient with High Purin Diet

Author : Lailatul Muniroh, SKM, M.Kes


Year : 2010

Abstact :

Increased concentrations of crystal monosodium urea at joint and soft tissue represent induced of inflammation at gout arthritis (GA). Incidence and prevalence GA disseminate wide in developed countries in Asian range from 2-15% and In Indonesia, GA prevalence was 29% and mostly found in Minahasa, Toraja, and Batak ethnics. This research was aimed to analyze application of curcuma domestica volatile oil as anti inflammation agent on gout arthritis patient who has high purin diet and to assess specific cellular mediator Tumor Necrosis Factor-α (TNF-α). The design of the study was randomized pretest-posttest control group design with single blind treatment. The GCMS test was performed to identify active component in volatile oil. The sample was the new gout arthritis patient in Haji Public Hospital Surabaya. For a week, treatment group was assigned with volatile oil with dose 25 mg/kg body weight and the control group was given indometasin 150 mg/kg body weight. Blood samples were taken before and after treatment. Volatile oil of curcuma domestica (Curcuma domestica, val) has four fraction of active component. There was decreasing in blood urea level in treatment group (p = 0,001) and control group (p = 0,007). Both in control and treatment group, there was also decreasing in TNF-α, however it was not statistically significant.


Keyword : Curcuma domestica volatile oil, ELISA, gout artritis, Tumor Necrosis Factor-α,


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