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Penelitian

Dr. Ferdiansyah, dr., Sp.OT.

ferdyortho@yahoo.com.

Fakultas Kedokteran / Departemen Ilmu Bedah Ortopedi & Traumatologi

Tim Peneliti :

  1. Ferdiansyah
  2. Heri Suroto
  3. Lintong Nainggolan --> Peneliti Utama

Tahun : 2010

Halaman Naskah : 62 halaman

Sumber Dana : Mandiri

Besaran Dana : 20000000

SK. Penetapan : Mandiri

Publikasi : :

Kategori Penelitian : Kesehatan

Posting : 03-01-2012

Visitor : 5594


Download Article : PDF 3345 byte.


Title :

Pengaruh Mesenchymal Stem Cells Yang Berasal Dari Bone Marrow Pada Penyembuhan Tendon Achilles Kelinci

Author : Dr. Ferdiansyah, dr., Sp.OT.


Year : 2010

Abstact :

Background

            Tissue engineering techniques have shown promise in the treatment of tendon and ligament defects. The present study tested the hypothesis that bone marrow derived mesenchymal stem cells can accelerate tendon healing after primary repair of tendon injury in  rabbit  models.

 

Methods

            Fiveteen New Zealand White rabbits were used as experimental animals. The injury model was sharp complete transection trough midsubstance of achiles tendon. The transected tendon immediately repaired with use of a modified Kessler suture and a running  epitendineous suture. Both limb were used, one part receive bone marrow derived stem cells and the counter part limb as control. Post operatively, both limb were not immobilized. Specimens were harvested at fourth  weeks  for analysis of  fibroblast assessment  and mechanical testing

Results

There were significant differences between the two groups with regard to the mechanical testing results ( tensile strength and maximal modulus elasticity) and also there were significant improvement of fibroblast at repair site of transected achiles tendon compared to control tendons

 

Conclusions

            Intratendineus cell theraphy with bone marrow derived mesenchymal stem cell following primary  tendon repair can improve fibroblast and biomechanical parameters in the early stage of tendon healing.


Keyword : Mesenchymal stem cells, bone marrow, modulation of tendon healing, biomechanical properties, fibriblast,


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