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Penelitian

Dr. Juniastuti, dr., M.Kes.

Fakultas Kedokteran / Departemen Mikrobiologi Kedokteran

Tim Peneliti :

  1. Juniastuti --> Peneliti Utama
  2. Ni Made Mertaniasih
  3. Maria Lucia Inge Lusida
  4. Victor Eka Nugrahaputra
  5. Mochamad Amin

Tahun : 2009

Halaman Naskah : 6 halaman

Sumber Dana : Risbiniptekdok

Besaran Dana : 100000000

SK. Penetapan :

Publikasi : Media Jurnal : Microbiology Indonesia

Kategori Penelitian : Kesehatan

Posting : 23-06-2012

Visitor : 1736


Download Article : PDF 2883 byte.


Title :

The Relatedness between Hepatitis B Virus from Non-Papuan Blood Donors in Jayapura and the Papuan Clusters.

Author : Dr. Juniastuti, dr., M.Kes.


Year : 2009

Abstact :

The genotypes (A-H) and subtypes (adw2, adw4, adrq-, adrq+, ayw1-4, ayr) of HBV show distinct geographical distributions, which have been associated with anthropological history.  The novel finding of the HBV subgenotypes C6 and D6 from Papuans formed a specific cluster distinct from the previous HBV subgenotypes C1-C5 and D1-D5. In this study we determined the most recent genotype-subtype patterns of the HBV from non-Papuan blood donors who live in Jayapura and their phylogenetic relatedness, especially with the Papuan clusters.  Fifteen HBsAg-positive serums were obtained from non-Papuan blood donors including from people in Java (46.7%), Maluku (26.7%), Sulawesi (20%) and East Nusa Tenggara (6.7%).  S gene of all HBV serum
isolates were partially sequenced and analyzed. Most HBV isolates (53.3%) were classified as genotype B, followed by genotype C (26.7%) and D (20.0%).  The subtype  adw2  (33.3%) was predominant, followed by adrq+  (26.7%) and ayw1/ayw2  (20.0%).  All HBV isolates with subtype  adw2  and  ayw1  belonged to genotype B, while adrq+ belonged to genotype C and ayw2 belonged to genotype D.  The most predominant HBV genotype-subtype (B/adw2) was consistent with the ethnic background (mostly from Java people).  Nevertheless, based on the phylogenetic relatedness, many non Papuan isolates (40%) were classified into HBV/C6 and HBV/D6 of the Papuan clusters.  Other isolates were classified into HBV/C1, HBV/B3 and HBV/B7.  In conclusion, many HBV isolates from non-Papuans in Jayapura belonged to the Papuan clusters, but others had different genotype-subtype patterns with frequencies dependent on ethnicity.


Keyword : hepatitis B virus, genotypes, subtypes, phylogenetic relatedness,


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